Functional screening in ETO2-GLIS2 pediatric AML

Screening of ETO2-GLIS2-induced Super Enhancers identifies targetable cooperative dependencies in acute megacaryoblastic leukemia.

Resulting from a collaboration between the teams of Julie Chaumeil (ATIP-Avenir, Institut Cochin), Thomas Mercher and Camille Lobry (Inserm U944, Institut Saint-Louis), this study reveals the importance of a functional module controlled by the ETO2-GLIS2 fusion oncogene, including two receptor tyrosine kinases mediating extracellular signals, in pediatric acute megakaryoblastic leukemia.