Location:
Institut Imagine
24 Boulevard du Montparnasse Paris 15

The aim of the symposium is to bring together the pediatric cancer community to discuss advances in our understanding of the origins and causes of cancer development and the associated therapeutic perspectives. The symposium will address several areas of cancer research, including epidemiological and genetic risk factors, the role of development in tumor initiation, modelising the complex biology of tumors development, and novel therapeutic strategies.

Target audience: physicians, clinicians, basic researchers, biologists, trainees, medical students.

Confirmed speakers are indicated below.

Confirmed speakers

Scott A. Armstrong

Dana-Farber Cancer Institute, USA

Franck Bourdeaut

Institut Curie, France

Guillaume Canaud

Hôpital Necker, France

Mario Capasso

University of Naples Frederico II, Italy

Céline Delloye-Bourgeois

CRCL, France

Jarno Drost

Princess Maxima Center, Netherlands

Friederike Erdmann

IMBEI, Germany

Mariella Filbin

Boston Children’s Hospital, USA

Alain Fischer

Institut Imagine, France

Birgit Geoerger

Gustave Roussy, France

Florent Ginhoux

Gustave Roussy, France

Cédric Maurange

IBDM, France

Katrin Ottersbach

University of Edinburgh, UK

Michael D. Taylor

Baylor College of Medicine – Texas Children’s Hospital, Houston

Program

Wednesday May 29 th

12:00-19:00

12:00-13:00

Welcome coffee

13:00-13:35

How genetic defects of the immune system predispose to cancer
Alain Fischer, Institut Imagine, Paris, France

Session 1 – Risk factors in childhood cancers

13:35-14:10

Unravelling Genetic Predisposition to Neuroblastoma: Implications and Relevance in Clinical Settings
Mario Capasso, University of Naples Federico II CEINGE Biotecnologie Avanzate, Italy

14:10-14:30

Environmental risk factors of childhood cancers – recent results of the GEOCAP project
Stéphanie Goujon, Hôpital Brousse, Villejuif, France

14:30-14:45

Wilms tumour: a systematic review and meta-analysis of environmental risk factors
Felix Onyije, Centre international de recherche sur le cancer, Lyon, France

14:45-15:00

Selected talks

15:00-15:15

The synergistic impact of exposures to mycotoxins and Epstein Barr virus (EBV) at early stages of Burkitt lymphomagenesis
Rita Khoueiry, Centre international de recherche sur le cancer, Lyon, France

15:15-15:30

Origins of Second Malignancies in Children
Mònica Sánchez-Guixé, Institute for research in biomedicine, Barcelona

15:30-16:00

Coffee break

16:00-16:35

Childhood cancer incidence and paediatric cancer care during the COVID-19 pandemic in Germany: Any new aetiological insights from the pandemic?
Friederike Erdmann, Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center of the Johannes Gutenberg University Mainz, Germany

16:35-17:00

Molecular and genetic basis of Epstein Barr virus-associated childhood lymphoma
Sylvain Latour, Institut Imagine, Paris, France

17:00-19:00

Poster Session

Thursday May 30 th

8:30-18:00

8:30-9:00

Welcome coffee

Session 2 – Ontogenic determinants of pediatric oncogenes specificities

9:00-9:35

The developmental origins of infant leukaemia
Katrin Ottersbach, University of Edinburgh, Edinburgh, United Kingdom

9:35-10:10

SMARCB1-deficient Rhabdoid tumors : one single gene, multiple lineages
Franck Bourdeaut, Institut Curie, Paris, France

10:10-10:25

ALK-induced lymphomagenesis: from CRISPR modeling to the identification of new regulators by OMICs analyses
Rosalie Borry, Institut Imagine, Paris, France

10:25-10:40

Single-cell data integration reveals age-associated gene regulatory networks in t(8;21) acute myeloid leukaemia
Jessica Whittle, Cancer Research UK Manchester Institute, Manchester

10:40-11:10

Coffee break

11:10-11:25

Cancer-specific epigenome identifies oncogenic hijacking by nuclear factor I family proteins for medulloblastoma progression
Gabriele Cancila, Institut Curie, Orsay

11:25-11:45

Deciphering the impact of MYCN overexpression and Alk activation on the sympathoadrenal lineage and neuroblastoma oncogenesis
Isabelle Janoueix-Lerosey, Institut Curie, Paris, France

11:45-12:20

Insights into the spatio-temporal dynamics of neuroblastoma metastasis: embryonic mechanisms at the heart of the process
Celine Delloye-Bourgeois, Centre de Recherche en Cancérologie de Lyon, Lyon, France

12:20-13:30

Lunch

Session 3 – Integrated biology of tumor development

13:30-14:05

Medulloblastoma arises secondary to failure of differentiation of the Homo sapiens rhombic lip
Michael D. Taylor, 
Texas Children’s Hospital, Houston

14:05-14:40

Proteo-metabolomics integration reveals MYC functions in Medulloblastoma
Olivier Ayrault, Institut Curie, Orsay, France

14:25-15:00

Developmental origins and plasticity of high-grade glioma
Mariella Filbin, Boston Children’s Hospital, Boston

15:00-15:15

Deconstructing and reconstructing the predisposition to brain tumors in patients with Li- Fraumeni Syndrome
Marco Bruschi, Gustave Roussy, Villejuif, France

15:15-15:30

Identification of a subtype of mesenchymal stromal cells favoring leukemic stem cells in poor prognosis pediatric AML
Sylvain Lefort, Centre de recherche en cancérologie, Lyon, France

15:30-16:00

Coffee break

16:00-16:15

The graft of Medulloblastoma cells in the primitive cerebellum of a chick embryo allows the observation of phenotypic features reflecting their cells of origin and recapitulates the heterogeneity of the pathology
Servane Tauszig-Delamasure, Institut NeuroMyogène, Lyon

16:15-16:30

Proteomic analysis reveals AMBRA1 as a new CRL3 REN/KCTD11 substrate promoting Sonic Hedgehog-dependent medulloblastoma
Irene Basili, Institut Curie, Orsay, France

16:30-16:50

Modeling cell states in childhood cancers to improve the design of rationalized therapeutic combinations
Marie Castets, Centre de recherche en cancérologie, Lyon, France

16:50-17:25

Organoids in pediatric cancer research
Jarno Drost, Princess Máxima Center, Utrecht, Pays-Bas

17:25-18:00

Tumor Macrophage Heterogeneity
Florent Ginhoux, Gustave Roussy, Villejuif, France

Friday May 31 st

8:30-16:00

8:30-9:00

Welcome coffee

Session 4 : Development, dependencies and therapeutic perspectives

9:00-9:35

Extracting principles of cellular hierarchy from a minimal developmental tumor
Cédric Maurange, Institut de biologie du développement de Marseille, Marseille, France

9:35-9:50

Deciphering the impact of genetic mutations during developmental hematopoiesis
Alina Sommer, Institut Pasteur, Paris, France

9:50-10:05

Onco-fetal reprogramming is associated with high-risk juvenile myelomonocytic leukemia and creates therapeutic vulnerabilities in leukemia stem cells
Daniel Lipka, National Center for Tumor Diseases Heidelberg & German Cancer Research Center , Heidelberg, Germany

10:05-10:25

Early steps of pediatric acute megakaryoblastic leukemia development from normal human cells
Thomas Mercher, Gustave Roussy, Villejuif, France

10:25-10:40

Modeling pediatric ETO2::GLIS2-driven acute megakaryoblastic leukemia in human CD34+ cells uncovers a therapeutically targetable ontogeny-related cytokine-dependency for leukemia expansion
Klaudia Galant, CEA, Fontenay-aux-Roses, France

10:40-11:10

Coffee break

11:10-11:25

Development and characterization of organoids derived from pediatric brain tumors for fundamental and translational research
Clémence Deligne, Centre de recherche en cancérologie de Lyon, Lyon, France

11:25-11:40

DNMT3B, more than DNMT3A, as a major player and therapeutic target in rhabdoid tumors
Céline Chauvin, Institut Curie, Paris, France

11:40-11:55

CDKN1A is a target for phagocytosis-mediated cellular immunotherapy in acute leukemia
Awatef Allouch, Gustave Roussy, Villejuif, France

11:55-12:30

Targeting chromatin complexes in cancer
Scott A. Armstrong, Dana-Farber Cancer Institute, Boston, USA

12:30-14:00

Lunch

14:00-14:20

Enfants Cancer Santé and André Khayat award ceremony

14:20-14:40

Combination of low doses of irradiation with immunotherapy in AT/TR
Celio Pouponnot, Institut Curie, Orsay, France

14:40-15:15

Drug repositioning for patients with rare genetic disorders
Guillaume Canaud, Hôpital Necker-Enfants Malades, Paris, France

15:15-15:50

Pediatric Precision Cancer Medicine trials
Birgit Georger, Gustave Roussy, Villejuif, France

16:00 – End

Registration

Registration fees (3-day admission, including light lunches):
-Regular: 150 €
-Junior (student, post-doc, engineer, 36 years and younger): 50 €

Please fill in the form with the following information:
– Congress name/Workshop: “PEDIAC symposium 2024”
– Beneficiary of invoice: “INSERM DR PARIS IDF SUD”

For general information, please contact symposium2024@programme-pediac.com
For specific information regarding order forms please contact grepa-paris11@inserm.fr

Pratical information

Location: the symposium will be held at Institut Imagine, 24 Boulevard du Montparnasse, Paris 75015. Join us at the Auditorium on the 6 th floor.

Public transport

METRO:
-Line 12, station Falguière
-Lines 10 et 13, station Duroc
-Lines 4, 6, 12 and 13, station Montparnasse
TGV station Montparnasse
BUS Line 89 station Maine – Vaugirard
PLANE take transportation from Charles de Gaulle and Orly airports

Sponsors

We greatly appreciate the support from our sponsors.

Major sponsor